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KMID : 0604520180440030219
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Journal of the Society of Cosmetic Scientists of Korea
2018 Volume.44 No. 3 p.219 ~ p.229
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Studies on Cosmeceutical Activity of Extracts of Moringa oleifera Extract
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Kim So-Ra
Yoo Dan-Hee
Yeom Hyeon-Ji
Oh Min-Jeong
Lee Jin-Young
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Abstract
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The purpose of this study was to investigate the role of the Moringa oleifera (M. oleifera) extract as a cosmetic additive. The tyrosinase and elastase inhibitory effects showed 47% and 39% at 1,000 μg/mL concentration, respectively. Also, the collagenase inhibition effect was 31% at 500 μg/mL concentration. A cell viability test, measured on macrophage cell (RAW 264.7) and melanoma cell (B16F10) by ethanol extract of M. oleifera, showed 94.2% and 94.8% at 100 μg/mL concentration, respectively. In order to confirm anti-inflammatory activity, we examined the inhibitory effects on the production of lipopolysaccharides (LPS)-induced NO in RAW 264.7 cells by Griess assay. As a result, the M. oleifera extract showed a concentration-dependent inhibition of NO production. The protein expression inhibitory effects of M. oleifera extract were measured by western blot at 25, 50, 100 μg/mL concentration and the β-actin. Results showed that the expression inhibition rates of the iNOS, COX-2, MITF, TRP-1, TRP-2, tyrosinase protein were decreased by 85.8%, 57.5%, 80.7%, 30%, 29.9%, 23.6% at 100 μg/mL concentration, respectively. It was concluded that M. oleifera extracts had the anti-inflammatory and whitening effects and thus could be applied for cosmetics as a natural ingredient.
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KEYWORD
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Moringa oleifera, anti-inflammatory, whitening
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